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Diagnostic Accuracy of Presepsin versus Procalcitonin in Early-Onset Neonatal Septicaemia: A Prospective Cohort Study |
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Prasidutt Sharma, Khurshed Alam Choudhury, Shubhi Agarwal 1. Assistant Professor, Department of Paediatrics, UIMS, Prayagraj, Uttar Pradesh, India. 2. Assistant Professor, Department of Paediatrics, UIMS, Prayagraj, Uttar Pradesh, India. 3. Senior Resident, Department of Paediatrics, UIMS, Prayagraj, Uttar Pradesh, India. |
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Correspondence Address : Dr. Prasidutt Sharma, 54/32, Chhota Baghara, Prayagraj, Uttar Pradesh-211003, India. E-mail: prashidutt24@gmail.com |
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| ABSTRACT |  | ||||||
: Introduction: As a systemic inflammatory condition, neonatal sepsis causes serious morbidity and mortality. Septic shock and multiple organ dysfunction are swift, life-threatening consequences. For survival, early diagnosis and treatment are cardinal necessities. There is a need to evaluate biomarkers that can fulfill these requirements to increase survival. Aim: To compare the emerging diagnostic roles of Presepsin (P-SEP) and Procalcitonin (PCT) at 48 to 72 hours of life in Early-onset Neonatal Sepsis (EONS) patients. Materials and Methods: This prospective cohort study was conducted in the Neonatal Intensive Care Unit (NICU) of Mayo Medical College Barabanki, Uttar Pradesh, India from November 2019 to March 2021. A total of 58 cases at 48 to 72 hours of life, presenting with clinical features or risk factors of EONS, and 58 controls were included for blood culture, P-SEP, and PCT estimation. Comparison of quantitative variables between the study groups was conducted using the Mann-Whitney U test. The Chi-square (χ²) test and Fisher’s-exact test were used when the expected frequency was <5 for comparing categorical data. Receiver Operating Characteristic (ROC) curve analysis was performed, and the criterion value was estimated based on specificity and sensitivity. Results: A total of 58 cases and 58 healthy controls were included. Out of the 58 cases, 36 (62.06%) were male, and 22 (37.94%) were female, with a mean age of 35 weeks±1.12 SD. A total of 28 were Blood Culture Positive (BCP). In ROC curve analysis, at a specific cut-off value, the sensitivity of P-SEP and PCT was 82.76% and 62.07%, respectively, while the specificity was 89.66% and 96.55%, respectively. Conclusion: The P-SEP stands out as a superior biochemical marker compared to PCT. It has a promising future as an efficient sepsis detector and a positive indicator to avoid unnecessary NICU admissions and limit antibiotic therapy due to its high Negative Predictive Value (NPV). | |||||||
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| Keywords : Biochemical marker, Blood culture, Life-threatening consequences, Septic shock | |||||||
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DOI and Others :
DOI: 10.7860/IJNMR/2025/76365.2437
Date of Submission: Oct 17, 2024 Date of Peer Review: Dec 06, 2024 Date of Acceptance: Jan 17, 2025 Date of Publishing: Mar 31, 2025 AUTHOR DECLARATION: • Financial or Other Competing Interests: None • Was Ethics Committee Approval obtained for this study? Yes • Was informed consent obtained from the subjects involved in the study? Yes • For any images presented appropriate consent has been obtained from the subjects. NA PLAGIARISM CHECKING METHODS: • Plagiarism X-checker: Oct 18, 2024 • Manual Googling: Jan 10, 2025 • iThenticate Software: Feb 19, 2025 (14%) ETYMOLOGY: Author Origin EMENDATIONS: 9 |
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