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Mortality and Morbidity among Neonates Born to COVID-19 Positive Mothers in a Tertiary Care Hospital, Chennai: An Ambispective Cohort Study |
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Rajagopal Velu Aswini, Sridevi A Naaraayan, Krishnaswami Devimeenakshi 1. Junior Resident, Department of Paediatics, Government Kilpauk Medical College, Chennai, Tamil Nadu, India. 2. Associate Professor, Department of Paediatics, Government Kilpauk Medical College, Chennai, Tamil Nadu, India. 3. Professor, Department of Paediatics, Government Kilpauk Medical College, Chennai, Tamil Nadu, India. |
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Correspondence Address : Dr. Krishnaswami Devimeenakshi, Professor, Department of Paediatics, Government Kilpauk Medical College, Poonamalle High Road, Kilpauk, Chennai-600010, Tamil Nadu, India. E-mail: drdevi_1804@yahoo.in |
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| ABSTRACT |  | ||||||
: Introduction: The Coronavirus Disease-2019 (COVID-19) pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus, has had varied clinical impacts across different age groups. Understanding the morbidity and mortality rates among neonates born to COVID-19 positive mothers is crucial for ensuring preparedness within the healthcare system. Aim: To compare the morbidity and mortality rates of newborns born to COVID-19 positive and negative mothers. Materials and Methods: This ambispective cohort study was conducted at a tertiary care hospital in Chennai, Tamil Nadu, India between August 2021 and October 2022. Newborns born to mothers with COVID-19 at the time of delivery were classified as cases, while newborns born to the next two COVID-19 negative pregnant women who delivered immediately after the COVID-19 positive mother were considered as controls. The study included a sample of 214 COVID-19 positive mothers and 426 COVID-19 negative mothers. Clinical data were recorded, and all newborns were followed for one week to assess their morbidity and outcomes. Logistic regression analysis was performed to determine whether COVID-19 infection is a risk factor for adverse neonatal outcomes. Results: Among the newborns, 357 (55.8%) were females, and 333 (52%) were delivered via caesarean section. Of the newborns, 39 (6.1%) were preterm and 95 (14.8%) had low birth weight. The overall mortality rate was 1.25%. Four (1.8%) neonates tested positive for COVID-19. Logistic regression analysis revealed that caesarean section, respiratory distress syndrome, and prematurity were statistically significant morbidities associated with maternal COVID-19 positive status. The odds ratios (with 95% confidence intervals) were 4.090 (2.840-5.882) for caesarean section, 2.291 (1.508-3.480) for respiratory distress syndrome, and 2.359 (1.181-4.712) for prematurity. The mortality and other morbidities were similar between the two groups. Conclusion: Respiratory distress syndrome and prematurity were the common morbidities observed in newborns born to COVID-19 positive mothers. | |||||||
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| Keywords : Caesarean section, Coronavirus infections, Pandemics, Preeclampsia, Premature birth, Respiratory distress syndrome | |||||||
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DOI and Others :
DOI: 10.7860/IJNMR/2023/62735.2394
Date of Submission: Jan 08, 2023 Date of Peer Review: May 03, 2023 Date of Acceptance: Aug 02, 2023 Date of Publishing: Dec 31, 2023 AUTHOR DECLARATION: • Financial or Other Competing Interests: None • Was Ethics Committee Approval obtained for this study? Yes • Was informed consent obtained from the subjects involved in the study? Yes • For any images presented appropriate consent has been obtained from the subjects. NA PLAGIARISM CHECKING METH |
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