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Year :2025
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Month :
January
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Volume :
13
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Issue :
1
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Page :
PO19 - PO23
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Diagnostic Accuracy of Presepsin versus Procalcitonin in Early-Onset Neonatal Septicaemia: A Prospective Cohort Study
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Correspondence Address :
Prasidutt Sharma, Khurshed Alam Choudhury, Shubhi Agarwal,
Dr. Prasidutt Sharma,
54/32, Chhota Baghara, Prayagraj-211003, Uttar Pradesh, India.
E-mail: prashidutt24@gmail.com
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Introduction: As a systemic inflammatory condition, neonatal sepsis causes serious morbidity and mortality. Septic shock and multiple organ dysfunction are swift, life-threatening consequences. For survival, early diagnosis and treatment are cardinal necessities. There is a need to evaluate biomarkers that can fulfill these requirements to increase survival.
Aim: To compare the emerging diagnostic roles of Presepsin (P-SEP) and Procalcitonin (PCT) at 48 to 72 hours of life in Early-onset Neonatal Sepsis (EONS) patients.
Materials and Methods: This prospective cohort study was conducted in the Neonatal Intensive Care Unit (NICU) of Mayo Medical College Barabanki, Uttar Pradesh, India from November 2019 to March 2021. A total of 58 cases at 48 to 72 hours of life, presenting with clinical features or risk factors of EONS, and 58 controls were included for blood culture, P-SEP, and PCT estimation. Comparison of quantitative variables between the study groups was conducted using the Mann-Whitney U test. The Chi-square (χ²) test and Fisher’s-exact test were used when the expected frequency was <5 for comparing categorical data. Receiver Operating Characteristic (ROC) curve analysis was performed, and the criterion value was estimated based on specificity and sensitivity.
Results: A total of 58 cases and 58 healthy controls were included. Out of the 58 cases, 36 (62.06%) were male, and 22 (37.94%) were female, with a mean age of 35 weeks±1.12 SD. A total of 28 were Blood Culture Positive (BCP). In ROC curve analysis, at a specific cut-off value, the sensitivity of P-SEP and PCT was 82.76% and 62.07%, respectively, while the specificity was 89.66% and 96.55%, respectively.
Conclusion: The P-SEP stands out as a superior biochemical marker compared to PCT. It has a promising future as an efficient sepsis detector and a positive indicator to avoid unnecessary NICU admissions and limit antibiotic therapy due to its high Negative Predictive Value (NPV).
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