Home
About Us
Issues
Authors
Reviewers
Users
Subscription
Our Other Journals
Neonatal Database
Neonatal Database Download
Neonatal Journal Abstracts
Feedback
Salient Features
Open Access
Editorial Board
Publisher
Publication Ethics & Malpractice
Journal Policy
Peer Review Process
Contact Us
Current Issue
Forthcoming
Article Archive
Access Statistics
Simple Search
Advanced Search
IJNMR Performance
Submit an Article
Instructions
Assistance
Publication Fee
Paid Services
Apply As Reviewer
Acknowledgment
Register Here
Register For Article Submission
Login Here
Login For Article Submission
Annual
Buy One Issue
Payment Options
How to Order
JCDR
IJARS
NJLM

 

Welcome : Guest

Users Online :

 

 

 

 

 

 

 

 

Original article / research

Year :2024 Month : October Volume : 12 Issue : 4 Page : PO12 - PO16

Seroprevalence of TORCH Infection in Paediatric Population and Women of Reproductive Age Group: A Cross-sectional Study

 
Correspondence Address :
Radhika Chaudhary, Sangram Singh Patel, Richa Sinha, Nidhi Tejan, Akshay Arya, Chinmoy Sahu,
Sangram Singh Patel,
Associate Professor, Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow-226014, Uttar Pradesh, India.
E-mail: sangramsgpgi@gmail.com
Introduction: The acronym ‘TORCH’ complex includes infections due to Toxoplasma gondii, as well as others such as Syphilis, Hepatitis B, Rubella virus, Cytomegalovirus (CMV), and Herpes Simplex Virus (HSV), respectively. Primary infections due to these agents during pregnancy are associated with congenital malformations in newborns. Seroprevalence data is important to gather estimates of immunity levels, vaccination status, as well as levels of exposure, and will correlate with the risk of acquiring infections during pregnancy.

Aim: To determine the seroprevalence of TORCH infections in paediatric populations with suspected clinical conditions and women of reproductive age group, and also to assess the associated risk factors in mothers and newborns, and evaluate their clinical outcomes.

Materials and Methods:
This cross-sectional study was conducted between January 2019 and January 2022 in the Serology laboratory of the Department of Microbiology at the Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. A total of 92 consecutive antenatal females for whom TORCH antibody levels were determined and 343 suspected neonatal/paediatric populations were included in the study. The serum samples were subjected to IgM and IgG TORCH Enzyme Linked Immunosorbent Assay (ELISA). Demographic data and clinical details of patients were analysed from the Hospital Information System (HIS) and data records maintained in the department. Categorical variables are expressed as numbers and percentages.

Results: A total of 435 samples (343 paediatric and 92 women) were screened for TORCH infection in the laboratory. A total of 57 (13.1%) were seropositive for TORCH infection. The most commonly affected were infants (28 days- 1 year). Among the total screened population, the positive cases of CMV were 40 (9.1%), rubella 11 (2.5%), and toxoplasma 6 (1.3%). Biliary Atresia (BA) and neonatal cholestasis were the most common clinical conditions associated with CMV infection.

Conclusion: A high seroprevalence of IgM-specific CMV (9.1%) was observed in the present study. BA and neonatal cholestasis were the common complications in neonates associated with CMV infection.
 
[ FULL TEXT ]   |   [ ]
 

Article Utilities

  • Readers Comments
  • Article in PDF
  • Citation Manager
  • Article Statistics
  • Link to PUBMED
  • Print this Article
  • Send to a Friend

Quick Links

REVIEWER
ACCESS STATISTICS
Home  |  About Us  |  Online First  |  Current Issue  |  Simple Search  |  Advance Search  |  Register  |  Login  |  Contact  | 
IJNMR Pre-Publishing  |  Reviewer  |  Articles Archive  |  Access Statistics
© 2023 INDIAN JOURNAL OF NEONATAL MEDICINE & RESEARCH (IJNMR), ISSN : 2277-8527.
EDITORIAL OFFICE : 3rd Floor, Hemraj Jain Building, 4352 Pahari Dhiraj, Delhi, India 110006,Phone : 01123848553

* This Journal is owned and run by medical professionals *