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Year :2020
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Month :
October
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Volume :
8
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Issue :
4
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Page :
PO34 - PO38
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Umbilical Cord Serum Lipid Profile of Normal Preterm Neonates and Preterm Neonates with Respiratory Distress Syndrome: A Hospital-Based Cross-sectional Study
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Correspondence Address :
Ram Narain Sehra, Ankush Garg, Suniti Verma,
Dr. Ram Narain Sehra,
G-63, Tirupati Nagar, Jagatpura, Jaipur-302017, Rajasthan, India.
E-mail: rnsehra@gmail.com
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Introduction: Respiratory Distress Syndrome (RDS) is a common cause of morbidity and mortality in preterm neonates. Levels of minor phospholipids and lecithin in amniotic fluid are significantly influenced by lipid metabolism.
Aim: To evaluate umbilical cord lipid profile of preterm infants with RDS and normal preterm group without RDS.
Materials and Methods: This was a hospital-based cross-sectional study carried out in neonatal unit of at a Tertiary Care Centre at SMS Medical College, Jaipur, from June 2017 to May 2018. Out of total 80 preterm infants, 40 developed RDS and 40 infants served as controls. Umbilical cord blood lipid profile of neonates were done in both the groups and compared. Chi-Square test and unpaired Student’s t-test were used for statistical analysis. Probability was considered significant if less than 0.05
Results: Mean weight of babies was 1494.75±201.66 grams in normal preterm group and 1450.25±233.23 grams in preterm with RDS group (p=0.364). Mean gestational age was 31.45±1.36 weeks in normal preterm group and 30.98±1.49 weeks in preterm with RDS group p=0.140). Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL) were higher in male babies in both the groups as compared to female babies (p>0.05). Mean cord blood Triglyceride (TG), Total Cholesterol (TC), Very Low Density Lipoprotein (VLDL), LDL and HDL levels were significantly lower in preterms with RDS as compared to normal preterms without RDS which was statistically significant (p<0.05). Mean cord blood TG, TC, VLDL and HDL levels in all gestational age were higher in normal preterm as compared to preterm with RDS (p<0.05), except for LDL on 34-36 weeks age.
Conclusions: Preterm newborns with lower cord serum lipids may develop RDS. The cord blood, which is easily available, can be used for lipid levels at birth to predict RDS.
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