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Year :2017
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Month :
July
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Volume :
5
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Issue :
3
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Page :
PO01 - PO05
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Drug Utilization Pattern of Antimicrobials in Neonatal Sepsis in a Tertiary Care Teaching Hospital, Indiaand
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Correspondence Address :
Narendra Behera, Jayanti Prava Behera,
Dr. Jayanti Prava Behera,
Associate Professor, Department of Pharmacology,
Or No. 4R/11, MKCG Medical College Campus,
Berhampur-760004, Odisha, India.
E-mail: pravabeherajayanti@yahoo.co.in
naribehera@yahoo.co.in
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Introduction: Neonatal sepsis is a major cause of neonatal mortality and treated with antibiotics. The antibiotic susceptibility pattern varies from place to place at any point of time. Antimicrobial resistance, a burning problem globally, is due to irrational use of antibiotics. Drug utilization study is a strong tool for evaluating rational use of antibiotics.
Aim: To evaluate the antimicrobial use pattern, to identify problems associated with rational drug utilization and to know the clinical outcomes of neonates under treatment with various antimicrobial regimens in neonatal sepsis. Also to suggest any steps can be taken for possible improvement in rational antimicrobials use in this condition.
Materials and Methods: This was a descriptive observational study conducted from June, 2015 to September, 2016 in a Tertiary Care Teaching Hospital, Odisha, India. The consecutive neonatal sepsis cases, admitted to SNCU, Paediatrics Department, were included. The protocol was approved by IEC and written informed consents were obtained from the parents/guardians prior to the study. Total 204 diagnosed, screen positive neonatal sepsis cases of 0 -28 weeks old and both the sexes were enrolled. Demographic data like age, sex, place of delivery, gestational age and birth weight and antibiotic use data as per WHO guide line for drug utilization study were recorded in a case record form. The categorical data were expressed in percentage and mortality data was analyzed using GraphPad Prism ver.0.7 by Chi square test and p<0.05 was considered as significant.
Results: EONS (Early Onset of Neonatal Sepsis) was more than LONS (Late Onset of Neonatal Sepsis). Neonatal sepsis predominantly affected male babies. Preterm, LBW (Low Birth Weight), home delivery and NVD (Normal Vaginal Delivery) cases were more associated this condition. All of them received empirical antibiotics such as ampicillin/cefotaxime combined with amikacin/gentamicin from EDL (Essential Drug List) and prescribed almost rationally. Though cure rate was good, the death percentage was quite alarming.
Conclusion: The empirical antibiotics were given to all cases of neonatal sepsis, selected from EDL. Though, in this study group the antibiotic use pattern found rational, death rate was still high. So further study regarding risk factors associated and awareness about preventive measures will be required.
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