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Year :2017
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Month :
April
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Volume :
5
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Issue :
2
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Page :
PO10 - PO15
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Serial Serum C-reactive Protein in the Diagnosis of Neonatal Sepsis: A Cross-sectional Study
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Correspondence Address :
Santhakumar Sundarapandian, Selvakumar Chinnakkannan, Shafath Ahmed M, Rashmi Ranjan Das,
Dr. Rashmi Ranjan Das,
Assistant Professor, Department of Paediatrics,
All India Institute of Medical Sciences
Sijua, Patrapada, Bhubaneswar-751019,
Odisha, India.
E-mail: dr_rashmipgi@yahoo.com
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Introduction: C-reactive Protein (CRP) is an acute phase reactant secreted in increased amounts in the early hours of acute inflammation.
Aim: To evaluate serial CRP levels for the diagnosis of neonatal infection and to do comparative analysis of CRP levels with other parameters of sepsis screen.
Materials and Methods: Neonates with birth weight >1500 g and suspected to have sepsis were included. CRP was measured from the serum by quantitative turbidimetric immunoassay. The CRP 1 level was measured at the time of clinical presentation; CRP 2 and CRP 3 were measured at 24 and 48 hours respectively.
Results: A total of 100 neonates were included. CRP was positive in 72% cases (CRP 2 in 59% and CRP in 72% cases). On comparative analysis of CRP with symptomatology, culture of the body fluid, WBC count, proven sepsis; serial CRP levels showed increase in sensitivity, decrease in specificity, not much change in Positive Predictive Value (PPV), but increase in Negative Predictive Value (NPV). CRP 3 was significantly associated with culture positivity.
Conclusion: Serial CRP measurements are useful in the diagnosis of neonatal sepsis. CRP 3 level may virtually rule out or rule in the diagnosis of neonatal sepsis, and has very good correlation with blood culture.
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