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Role of Therapeutic Hypothermia in Prevention of Acute Kidney Injury in Neonates with Perinatal Asphyxia- A Prospective Observational Study |
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Shubham Raheja, Payal Mittal 1. Senior Resident, Department of Paediatrics, FH Medical College, Agra, Uttar Pradesh, India. 2. Associate Professor, Department of Paediatrics, FH Medical College, Agra, Uttar Pradesh, India. |
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Correspondence Address : Shubham Raheja, 172-A, TDI City, Sector-23, Panipat-132103, Haryana, India. E-mail: shbhmrhj@gmail.com |
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| ABSTRACT |  | ||||||
: Introduction: Perinatal Asphyxia (PA) remains a leading cause of neonatal mortality, especially in resource-limited settings like India, contributing to over 13% of neonatal deaths. Acute Kidney Injury (AKI) is a significant complication of PA, with an incidence ranging from 50-72%. Therapeutic Hypothermia (TH), the only evidence-based intervention for Hypoxic Ischaemic Encephalopathy (HIE), has demonstrated neuroprotective effects. However, its renoprotective potential in preventing AKI is inadequately explored. Aim: To evaluate the role of TH in preventing AKI in term neonates with PA by comparing renal outcomes between neonates receiving TH and those receiving standard care. Materials and Methods: This prospective observational study was conducted in the Neonatal Intensive Care Unit (NICU) of FH Medical College in Agra, Uttar Pradesh, India, from September 2022 to May 2024. A total of 81 neonates with moderate to severe HIE were enrolled. The enrolled neonates were categorised into two groups: Group A received standard care (n=40), while Group B received TH (n=41). AKI was diagnosed according to the neonatal modified Kidney Disease: Improving Global Outcomes (KDIGO) criteria, and outcomes were monitored over a 72-hour period. Neurological outcomes were additionally assessed using the Thompson encephalopathy score. Data were analysed using Statistical Package for Social Sciences (SPSS) version 21.0, with a p-value <0.05 considered statistically significant. Results: The incidence of AKI was significantly lower in the TH group (31.7%) compared to the non TH (52.5%) (p=0.047*). Neonates in group B also demonstrated better neurological outcomes, with 73% achieving mild Thompson scores at discharge compared to 51.5% in group A. Complications like hypotension and coagulopathy showed no significant differences between groups. Conclusion: TH significantly reduces AKI incidence and improves neurological outcomes in neonates with PA, reinforcing its role in neonatal care. | |||||||
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| Keywords : Body cooling, Encephalopathy, Hypoxic-injury, Neonatal care, Renal insufficiency | |||||||
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DOI and Others :
DOI: 10.7860/IJNMR/2026/85478.2477
Date of Submission: Nov 20, 2025 Date of Peer Review: Jan 02, 2026 Date of Acceptance: Mar 12, 2026 Date of Publishing: Jun 30, 2026 AUTHOR DECLARATION: • Financial or Other Competing Interests: None • Was Ethics Committee Approval obtained for this study? Yes • Was informed consent obtained from the subjects involved in the study? Yes • For any images presented appropriate consent has been obtained from the subjects. NA PLAGIARISM CHECKING METHODS: • Plagiarism X-checker: Nov 24, 2025 • Manual Googling: Mar 06, 2026 • iThenticate Software: Mar 11, 2026 (2%) ETYMOLOGY: Author Origin EMENDATIONS: 6 |
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