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Incidence and Pattern of Morbidity among Neonates with Premature Rupture of Membranes: A Prospective Cohort Study |
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Thamaraikannan A Arulselvan, Sridevi A Naaraayan, Krishnaswami A Devimeenakshi 1. Resident, Department of Paediatrics, Kilpauk Medical College, Chennai, Tamil Nadu, India. 2. Associate Professor, Department of Paediatrics, Kilpauk Medical College, Chennai, Tamil Nadu, India. 3. Professor, Department of Paediatrics, Kilpauk Medical College, Chennai, Tamil Nadu, India. |
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Correspondence Address : Sridevi A Naaraayan, 16A, Landon Towers, 32, Landons Road, Kilpauk, Chennai-600010, Tamil Nadu, India. E-mail: childdoctorsri@yahoo.co.in |
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| ABSTRACT |  | ||||||
: Introduction: Conventionally, Premature Rupture of Membranes (PROM) lasting more than 18 hours is considered to be associated with neonatal morbidities. However, recent research has shown that PROM of shorter duration is also associated with neonatal morbidity. Aim: The present study was conducted to estimate the incidence and pattern of morbidity in neonates born following PROM of more than 12 hours. Materials and Methods: The present prospective cohort study was conducted in the Neonatal Intensive Care Unit (NICU) of Kilpauk Medical College, Chennai, Tamil Nadu, India. from September 2019 to September 2020. One hundred neonates born following PROM of more than 12 hours were recruited and followed until recovery. Their clinical morbidities, including sepsis and duration of hospital stay, were recorded. The primary outcome was expressed as proportion. Secondary outcomes were analysed using the Chi-square test, and a p-value less than 0.05 was considered statistically significant. Results: The mean {Standard Deviation (SD)} birth weight of the cohort was 2.84 (0.47) kg. Fourteen percent of the neonates were preterm, and 52% were male. The incidence of morbidity among the study population was 40%. The morbidities encountered in neonates born following PROM of more than 12 hours included respiratory distress, birth asphyxia, Small for Gestational Age (SGA), and sepsis. Morbidities were almost equal (41% vs 39%) in neonates born following PROM of 12-18 hours and more than 18 hours. Culture-positive sepsis and duration of hospital stay were higher in neonates born following PROM of more than 18 hours (p=0.017). The rate of culture-positive sepsis increased with longer duration of PROM (p=0.009). Conclusion: According to the present study findings, a significant number of neonates born following PROM of more than 12 hours experienced morbidities. Hence the conventional PROM cut-off of 18 hours should be reconsidered. | |||||||
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| Keywords : Birth asphyxia, Culture positive, Neonatal morbidity, Neonatal sepsis, Respiratory distress | |||||||
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DOI and Others :
DOI: 10.7860/IJNMR/2026/81750.2475
Date of Submission: Jul 02, 2025 Date of Peer Review: Sep 11, 2025 Date of Acceptance: Jan 12, 2026 Date of Publishing: Jun 30, 2026 AUTHOR DECLARATION: • Financial or Other Competing Interests: None • Was Ethics Committee Approval obtained for this study? Yes • Was informed consent obtained from the subjects involved in the study? Yes • For any images presented appropriate consent has been obtained from the subjects. No PLAGIARISM CHECKING METHODS: • Plagiarism X-checker: Jul 03, 2026 • Manual Googling: Jan 06, 2026 • iThenticate Software: Jan 10, 2026 (4%) ETYMOLOGY: Author Origin EMENDATIONS: 7 |
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