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Effective Role of Oral Sildenafil in the Treatment of Cystic Hygroma in an Infant: A Case Report |
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Sumit Jeena, Atul Londhe, Amol Joshi, LS Deshmukh 1. DM Neonatology 3rd Year Senior Resident, Department of Neonatology, GMC, Aurangabad, Maharashtra, India. 2. Associate Professor, Department of Neonatology, GMC, Aurangabad, Maharashtra, India. 3. Associate Professor, Department of Neonatology, GMC, Aurangabad, Maharashtra, India. 4. Professor, Department of Neonatology, GMC, Aurangabad, Maharashtra, India. |
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Correspondence Address : Sumit Jeena, Room No. 2, A-Block, Mard Hostel, Ghati Hospital, Aurangabad-431001, Maharashtra, India. E-mail: sumit.jeena@gmail.com |
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| ABSTRACT |  | ||||||
: Cystic hygroma is a benign congenital malformation of the lymphatic system. Most cystic hygromas are found in the neck; rarer locations include the axilla, mediastinum, and limbs. Symptoms range from incidental findings to significant morbidity due to compression of adjacent organs, infection, haemorrhage, etc. Treatment is primarily aimed at complete surgical resection. Other treatment modalities include sclerotherapy, radiotherapy, laser ablation, and medical therapy with sirolimus, but recurrence rates are high. Surgery is not always possible since Lymphatic Malformations (LMs) can be intertwined within muscles or organs, and incomplete resection of LMs can result in recurrence; hence, alternative therapies have been explored. Recently, authors reported a case of a full-term female infant with a left-sided cystic hygroma. There was marked regression of the cystic hygroma with oral sildenafil, a selective inhibitor of phosphodiesterase-5. | |||||||
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| Keywords : Lymphangiomas, Lymphatic malformations, Sclerotherapy | |||||||
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DOI and Others :
DOI: 10.7860/IJNMR/2025/79602.2451
Date of Submission: Mar 27, 2025 Date of Peer Review: Apr 27, 2025 Date of Acceptance: Aug 13, 2025 Date of Publishing: Sep 30, 2025 AUTHOR DECLARATION: • Financial or Other Competing Interests: None • Was informed consent obtained from the subjects involved in the study? Yes • For any images presented appropriate consent has been obtained from the subjects. Yes PLAGIARISM CHECKING METHODS: • Plagiarism X-checker: Mar 27, 2025 • Manual Googling: Jun 04, 2025 • iThenticate Software: Aug 11, 2025 (12%) ETYMOLOGY: Author Origin EMENDATIONS: 8 |
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Case report
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