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Year :2026
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Month :
April
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Volume :
14
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Issue :
2
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Page :
PO19 - PO23
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Role of Therapeutic Hypothermia in Prevention of Acute Kidney Injury in Neonates with Perinatal Asphyxia- A Prospective Observational Study
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Correspondence Address :
Shubham Raheja, Payal Mittal,
Shubham Raheja,
172-A, TDI City, Sector-23, Panipat-132103, Haryana, India.
E-mail: shbhmrhj@gmail.com
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Introduction: Perinatal Asphyxia (PA) remains a leading cause of neonatal mortality, especially in resource-limited settings like India, contributing to over 13% of neonatal deaths. Acute Kidney Injury (AKI) is a significant complication of PA, with an incidence ranging from 50-72%. Therapeutic Hypothermia (TH), the only evidence-based intervention for Hypoxic Ischaemic Encephalopathy (HIE), has demonstrated neuroprotective effects. However, its renoprotective potential in preventing AKI is inadequately explored.
Aim: To evaluate the role of TH in preventing AKI in term neonates with PA by comparing renal outcomes between neonates receiving TH and those receiving standard care.
Materials and Methods: This prospective observational study was conducted in the Neonatal Intensive Care Unit (NICU) of FH Medical College in Agra, Uttar Pradesh, India, from September 2022 to May 2024. A total of 81 neonates with moderate to severe HIE were enrolled. The enrolled neonates were categorised into two groups: Group A received standard care (n=40), while Group B received TH (n=41). AKI was diagnosed according to the neonatal modified Kidney Disease: Improving Global Outcomes (KDIGO) criteria, and outcomes were monitored over a 72-hour period. Neurological outcomes were additionally assessed using the Thompson encephalopathy score. Data were analysed using Statistical Package for Social Sciences (SPSS) version 21.0, with a p-value <0.05 considered statistically significant.
Results: The incidence of AKI was significantly lower in the TH group (31.7%) compared to the non TH (52.5%) (p=0.047*). Neonates in group B also demonstrated better neurological outcomes, with 73% achieving mild Thompson scores at discharge compared to 51.5% in group A. Complications like hypotension and coagulopathy showed no significant differences between groups.
Conclusion: TH significantly reduces AKI incidence and improves neurological outcomes in neonates with PA, reinforcing its role in neonatal care.
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