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Year :2026
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Month :
April
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Volume :
14
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Issue :
2
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Page :
PO11 - PO14
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Incidence and Pattern of Morbidity among Neonates with Premature Rupture of Membranes: A Prospective Cohort Study
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Correspondence Address :
Thamaraikannan A Arulselvan, Sridevi A Naaraayan, Krishnaswami A Devimeenakshi,
Sridevi A Naaraayan,
16A, Landon Towers, 32, Landons Road, Kilpauk, Chennai-600010, Tamil Nadu, India.
E-mail: childdoctorsri@yahoo.co.in
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Introduction: Conventionally, Premature Rupture of Membranes (PROM) lasting more than 18 hours is considered to be associated with neonatal morbidities. However, recent research has shown that PROM of shorter duration is also associated with neonatal morbidity.
Aim: The present study was conducted to estimate the incidence and pattern of morbidity in neonates born following PROM of more than 12 hours.
Materials and Methods: The present prospective cohort study was conducted in the Neonatal Intensive Care Unit (NICU) of Kilpauk Medical College, Chennai, Tamil Nadu, India. from September 2019 to September 2020. One hundred neonates born following PROM of more than 12 hours were recruited and followed until recovery. Their clinical morbidities, including sepsis and duration of hospital stay, were recorded. The primary outcome was expressed as proportion. Secondary outcomes were analysed using the Chi-square test, and a p-value less than 0.05 was considered statistically significant.
Results: The mean {Standard Deviation (SD)} birth weight of the cohort was 2.84 (0.47) kg. Fourteen percent of the neonates were preterm, and 52% were male. The incidence of morbidity among the study population was 40%. The morbidities encountered in neonates born following PROM of more than 12 hours included respiratory distress, birth asphyxia, Small for Gestational Age (SGA), and sepsis. Morbidities were almost equal (41% vs 39%) in neonates born following PROM of 12-18 hours and more than 18 hours. Culture-positive sepsis and duration of hospital stay were higher in neonates born following PROM of more than 18 hours (p=0.017). The rate of culture-positive sepsis increased with longer duration of PROM (p=0.009).
Conclusion: According to the present study findings, a significant number of neonates born following PROM of more than 12 hours experienced morbidities. Hence the conventional PROM cut-off of 18 hours should be reconsidered.
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