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Year :2025
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Month :
July
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Volume :
13
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Issue :
3
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Page :
PO01 - PO05
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Comparison of Cord Blood Lipid Profile among Appropriate for Gestational Age and Small for Gestational Age Term Neonates: A Cross-sectional Study
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Correspondence Address :
Jasim Qureshi, Saman Beg, Jaigham Abbas, Ashish Verma, Akanksha Srivastava, Khatibur Rahman,
Dr. Saman Beg,
Flat No. 302, Tower No. 8, Bloomberg Tower, Omaxe Heights, Vibhuti Khand, Gomti Nagar, Lucknow, Uttar Pradesh, India.
E-mail: samanbeg.alig@gmail.com
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Introduction: Antenatal factors such as prematurity and Intrauterine Growth Restriction (IUGR) may influence the levels of various cord blood lipoproteins and subsequently predispose infants to early-onset ischaemic heart diseases. In order to provide insight on abnormalities in the lipid profile as soon as feasible (at birth) among newborns, especially in term and Small for Gestational Age (SGA) infants, the need for present study arose so that these high-risk babies could be continuously monitored.
Aim: To estimate the cord lipid profile in term neonates and compare lipid levels between Appropriate for Gestational Age (AGA) and Small for Gestational Gge (SGA) infants.
Materials and Methods: This cross-sectional study was conducted on 130 neonates with gestational ages of 37-42 weeks in the Department of Paediatrics at the Career Institute of Medical Sciences and Hospital (CIMSH), Lucknow, Uttar Pradesh, India from December 2022 to May 2024. The neonates were divided into two groups: Group A consisted of 65 term neonates who were AGA, and Group B consisted of 65 term neonates who were SGA. Parameters assessed included Total Cholesterol (TC), Triglycerides (TG), High-Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL), and Very Low-Density Lipoprotein (VLDL). Pearson correlation was used to assess relationships between lipid profiles, gestational age and birth weight. Significance was set at p-value<0.05.
Results: Baseline characteristics, including gender distribution and birth weight, were comparable across groups (p-value>0.05). Group B (SGA) neonates exhibited significantly higher levels of TG, TC, LDL, and VLDL than Group A (AGA) (p-value<0.05). HDL levels, although higher in Group B, were not statistically significant (p-value>0.05). TC, HDL and LDL levels showed a significant negative correlation with gestational age and birth weight (p-value<0.05). TG and VLDL levels exhibited a weak and statistically insignificant correlation.
Conclusion: The SGA babies showed noticeably greater cord blood levels of LDL cholesterol, TG and TC than the AGA group of newborns. Therefore, it is important to routinely monitor SGA and low birth weight neonates throughout their adolescence and adulthood to implement prompt therapies and prevent the rapid development of cardiovascular disease.
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