Home
About Us
Issues
Authors
Reviewers
Users
Subscription
Our Other Journals
Neonatal Database
Neonatal Database Download
Neonatal Journal Abstracts
Feedback
Aims and Scope
Salient Features
Open Access
Editorial Board
Publisher
Publication Ethics & Malpractice
Peer Review Process
Contact Us
Current Issue
Online Ahead of Print
Forthcoming
Article Archive
Access Statistics
Simple Search
Advanced Search
Submit an Article
Instructions
Assistance
Publication Fee
Paid Services
Apply As Reviewer
Acknowledgment
Register Here
Register For Article Submission
Login Here
Login For Article Submission
Annual
Buy One Issue
Payment Options
How to Order
JCDR
IJARS
NJLM

 

Welcome : Guest

 

 

 

 

 

 

 

 

Original article / research

Year : 2019 Month : October-December Volume : 7 Issue : 4 Page : MO01 - MO08

Causative Agents, Antibiotic Resistance Patterns and Risk Factors in Early and Late Onset Neonatal Sepsis in a Neonatal Intensive Care Unit

 
Correspondence Address :
Dr. Nadire Seval Gündem,
Dr Ali Kemal Belviranl Gynecology, Obstetrics and Children Hospital, Yeni Stanbul Street, Konya, Selçuklu-42285, Turkey, Konya, Turkey.
E-mail: sevalgndem@yahoo.com
Introduction: Neonatal sepsis is one of the major causes of neonatal mortality. Causative agents, antibiotic resistance patterns and risk factors of sepsis differ from one region to another in the world. Periodic assessments of these will guide to use an appropriate antibiotics for rational empirical treatment and contribute to management of sepsis.

Aim: To determine causative agents, antibiotic resistance patterns and risk factors of early and late onset neonatal sepsis.

Materials and Methods: A total of 230 neonates diagnosed as sepsis were included in this retrospective study. Data collection was made by reviewing records of patients from laboratory and hospital information system of Konya Dr Ali Kemal Belviranli Gynaecology, Obstetrics and Children Hospital between September 2015-May 2017. Blood samples were incubated in automated blood culture system. Subcultures were performed on 5% sheep blood agar and eosin methylene blue agar. Identification of microorganisms was firstly made by conventional methods. Further identification and antibiotic susceptibility tests were performed by automatic analyser. Results were considered statistically significant at p<0.05.

Results: Early Onset Sepsis (EOS) was detected in 19 (8.3%) neonates while Late Onset Sepsis (LOS) occured in 211 (91.7%) of them. Coagulase-negative Staphylococcus was the most commonly isolated microorganisms in both early and late onset sepsis with rates of 84.2% and 81.5%, respectively. The rate of gram negative microorganisms was 13% and Enterobacteriaceae compose 8.7% of these. Klebsiella pneumoniae (3.5%) was the most common bacteria within Enterobacteriaceae. High methicillin resistance rates (81.2% and 83.7%) were observed in Coagulase negative Staphylococcus in both EOS and LOS, respectively. Enterobacteriaceae had extended spectrum beta-lactamase positivity rate of 63.2% and showed high resistance to ceftriaxone (63.2%) and cefuroxime (78.9%). No carbapenem resistance were detected in gram negative bacteria. No significant associations was found between onset of sepsis and gestational age, gender and mode of delivery (p>0.05).

Conclusion: There were some differences and also similarities between aetiologic agents and antibiotic resistance patterns among data obtained in this study and those from other countries. This study contributed to epidemiological information and routine antibiotic surveillance to use appropriate antibiotics for empirical treatment of sepsis and prevent its complications.
 
[ FULL TEXT ]   |   [ ]
 

Article Utilities

  • Readers Comments (0)
  • Article in PDF
  • Citation Manager
  • Article Statistics
  • Link to PUBMED
  • Print this Article
  • Send to a Friend

Quick Links

REVIEWER
ACCESS STATISTICS
Home  |  About Us  |  Online First  |  Current Issue  |  Simple Search  |  Advance Search  |  Register  |  Login  |  Contact  | 
IJNMR Pre-Publishing  |  Reviewer  |  Articles Archive  |  Access Statistics
© 2025 INDIAN JOURNAL OF NEONATAL MEDICINE & RESEARCH (IJNMR), ISSN : 2277-8527.
EDITORIAL OFFICE : 3rd Floor, Hemraj Jain Building, 4352 Pahari Dhiraj, Delhi, India 110006,Phone : 01123848553

* This Journal is owned and run by medical professionals *